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Medical Marijuana Laws Have Led to Substantial Increase in Use, Hospitalization of Kids

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Photo Credit: APIncreased use of medical marijuana may lead to more young children getting sick from accidentally eating food made with the drug, a Colorado study suggests.

Medical marijuana items include yummy-looking gummy candies, cookies and other treats that may entice young children. Fourteen children were treated at Colorado Children’s Hospital in the two years after a 2009 federal policy change led to a surge in medical marijuana use, the study found. That’s when federal authorities said they would not prosecute legal users…

Unusual drowsiness and unsteady walking were among the symptoms. One child, a 5-year-old boy, had trouble breathing. Eight children were hospitalized, two in the intensive care unit, though all recovered within a few days, Wang said. By contrast, in four years preceding the policy change, the Denver-area hospital had no such cases.

Some children came in laughing, glassy-eyed or “acting a little goofy and `off,”‘ Wang said. Many had eaten medical marijuana food items, although nonmedical marijuana was involved in at least three cases. The children were younger than 12 and included an 8-month-old boy.

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Study Finds New Way to Clear Cholesterol from Blood

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Scientists led by Prof David Ginsburg of the University of Michigan’s Howard Hughes Medical Institute inhibited the action of a gene responsible for transporting a protein that interferes with the ability of the liver to remove cholesterol from the blood in mice. Trapping the destructive protein where it couldn’t harm receptors responsible for removing cholesterol preserved the liver cells’ capacity to clear plasma cholesterol from the blood, but did not appear to otherwise affect the health of the mice.

In the research, scientists found that mice with an inactive SEC24A gene could develop normally. However, their plasma cholesterol levels were reduced by 45 percent because vesicles from liver cells were not able to recruit and transport a critical regulator of blood cholesterol levels called proprotein convertase subtilisin/kexin type 9 (PCSK9).

PCSK9 is a secretory protein that destroys the liver cells’ receptors of low-density lipoprotein (LDL, the so-called ‘bad cholesterol), and prevents the cells from removing the LDL.

“Inhibiting SEC24A or PCSK9 may be an alternative to statins, and could work together with statins to produce even greater effects,” said first study author Dr Xiao-Wei Chen from the Howard Hughes Medical Institute. “Also, they might be effective on patients who are resistant to or intolerant of statins.”

Initial studies of anti-PCSK9 therapies in humans have shown that eliminating PCSK9 can lower cholesterol dramatically and work with statins like Lipitor to lower it even further. The new study points to a new area for study: rather than inhibiting PCSK9 itself, perhaps future therapies could block the transport mechanism that allows the destructive protein to reach the LDL receptors.

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