Sexual and Gender Minorities More Likely To Have Adverse Brain Outcomes

People who identified as a sexual or gender minority (LGBTQ+) had a higher likelihood of adverse brain health outcomes, cross-sectional data showed.

Among nearly 400,000 participants in the All of Us research program, sexual and gender minority persons had higher odds of a composite outcome of stroke, dementia, and late-life depression than others (OR 1.15, 95% CI 1.08-1.22), reported Guido Falcone, MD, of Yale School of Medicine in New Haven, Connecticut, and co-authors in Neurology.

As a group, sexual and gender minority persons had significantly higher odds of late-life depression (OR 1.27, 95% CI 1.17-1.38).

The group trended toward higher odds of dementia (OR 1.14, 95% CI 1.00-1.29), which was significantly elevated among gender-diverse participants (assigned female at birth OR 1.94 95% CI 1.06-3.56; assigned male at birth OR 2.57, 95% CI 1.25-5.30).

Stroke risk was not higher for the overall group, but it was for transgender women (OR 1.68, 95% CI 1.04-2.70). (Read more from “Sexual and Gender Minorities More Likely To Have Adverse Brain Outcomes” HERE)