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Drug Can Reverse Alzheimer’s in One Week

alzheimersA drug that reversed Alzheimer’s in mice in only one week will be tested in people this year. The IL-33 protein reversed Alzheimer’s-like disease in mice, stopping cognitive decline in its tracks, according to joint research by the University of Glasgow and the Hong Kong University of Science and Technology (HKUST).

“IL-33 is a protein produced by various cell types in the body and is particularly abundant in the central nervous system — brain and spinal cord,” said Professor Eddy Liew of the University of Glasgow. “We carried out experiments in a strain of mice (APP/PS1) which develop progressive AD-like disease with aging.

We found that injection of IL-33 into aged APP/PS1 mice rapidly improved their memory and cognitive function to that of the age-matched normal mice within a week.”

Characteristics of Alzheimer’s include the amyloid plaque deposits and the formation of neurofibrillary tangles in the brain. As the disease progresses, plaques and tangles build, leading to the loss of connections between nerve cells. Eventually, the cells die, which causes the loss of brain tissue . . .

Although the researchers aren’t positive the protein will work in humans, they are optimistic. “Previous genetic studies have shown an association between IL-33 mutations and Alzheimer’s disease in European and Chinese populations,” said Liew. “Furthermore, the brain of patients with Alzheimer’s disease contains less IL-33 than the brain from non-Alzheimer’s patients. (Read more from “Drug Can Reverse Alzheimer’s in One Week” HERE)

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CDC Official: Syphilis Rates Among Gay Men Highest Since Before Start of HIV Epidemic

US-CDC-Logo (1)The rate of syphilis infection among homosexual men has increased to a level not seen since the start of the HIV/AIDS epidemic in the 1980s, an official with the Centers for Disease Control and Prevention (CDC) said on Capitol Hill Wednesday.

“We’re concerned about our high levels of syphilis among men who have sex with men – really we’re back to the level of disease – burden of disease – in gay men that we were seeing before HIV in this country,” said Gail Bolan, director of the CDC’s Division of STD Prevention.

She was speaking at an event held to lobby for federal funding to fight sexually transmitted diseases in the United States.

A CDC fact sheet on sexually-transmitted disease (STD) surveillance in 2014 refers to a “troubling rise in syphilis infections among men, particularly gay and bisexual men” . . .

“Men who have sex with men (MSM) account for 83 percent of male cases where the sex of the sex partner is known,” the fact sheet states. “Primary and secondary syphilis are the most infectious stages of the disease, and if not adequately treated, can lead to long-term infection, which can cause visual impairment and stroke.” (Read more from “CDC Official: Syphilis Rates Among Gay Men Highest Since Before Start of HIV Epidemic” HERE)

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FDA and the Spread of Brain Diseases

The U.S. Food and Drug Administration (FDA), charged with the mandate to protect the public’s food supply, openly admits its liability in the deaths of Americans, mostly in the form of heart attacks. That is far from the full story. What the giant government agency hides is its culpability in the recent rise in brain diseases that continue to claim both memory and lives.

A broad alert from the FDA should read:

· Research links processed foods to a proliferation of deadly brain diseases such as dementia and Alzheimer’s.

· Studies reveal a food ingredient is connected to memory loss that impacts learning acuity in schoolchildren and lessened productivity in the workplace among adults.

The FDA concedes that under its watch it has allowed so-called “Frankenstein oils” to permeate Americans’ processed food supply. On public record, the FDA states that partially hydrogenated oils (and their derivatives, trans fats), have caused thousands of heart attacks and deaths annually. The FDA would like it to be old news, swept under the rug. What the FDA hopes to bury from public knowledge is that the “killer oils” have proven to be more deadly than disclosed.

The bad oils that have been fed to Americans for over five decades have now been linked to the increase in deadly brain diseases. In an official release, the FDA admits that the laboratory-engineered oils cause “memory loss” without telling the full story to the American public of a scientific link to long-term, physical damage to the brains of people of all ages. The FDA’s admittance of wrongdoing evades full disclosure. The agency remains conspicuously mute on the recent scientific link of the oils to the sudden increase of incurable brain diseases. An early symptom, of which, is memory loss.

Among the scientists interviewed in the newly released book, “AGING: WARNING – Navigating Life’s Medical, Mental & Financial Minefields,” Dr. Beatrice A. Golomb, a renowned researcher at the University of California, San Diego, provides insight:

Q. Are “partially hydrogenated oils” and their derivatives, trans fats, toxic?
A. If “toxic” is defined by the ability to confer harm, then yes, overwhelmingly evidence indicates that trans fats/partially hydrogenated oils are “toxic”.

Q. These oils are notorious in scientific circles for being bad for the body; what is the mental impact?
A. The brain has a few important functions. One is regulation of mood. One is regulation of behavior (e.g. to control irritability/aggression). One is regulation of cognition [ability to think]. Our data have found trans fat [partially hydrogenated oil] consumption to be adversely linked to each of the three.

Q. Does this loss of memory indicate loss of brain cells?
A. Evidence shows that trans fats increase inflammation (brain inflammation is bad for memory) and increase oxidative stress, the kind of damage that antioxidants protect against – which is bad for memory – it can kill cells, and it can impair cell energy which can kill cells. But these effects can also impair function without killing cells.

Q. How does memory loss in young, working Americans, due to their consumption of these fats, [partially hydrogenated oils] impact their lives?
A. That was not an aspect of our study. But certainly, less favorable memory function is expected to translate to less favorable performance in school and in the workplace. Less favorable performance can constrain career choices, affect job performance, and thus influence career trajectories.

Q. What is the value, if any, for using industrially-fabricated oils in our processed food supply?
A. I used to tell my patients that trans fats improve the shelf life of the food, but reduce the shelf life of the person.

Of critical note is that the deadly oils will remain in the American processed food supply until mid-2018. An excerpt from the aforementioned book, provides further details on how these oils are linked to the build-up of a sticky and deadly protein scientifically known as beta-amyloids. Beta-amyloids wreak havoc as they flow through the cardiovascular system to the brain and eventually attack brain cells:

“A build-up in the brain and blood vessels of a protein plaque called beta-amyloids may be spurred or exacerbated by a build-up of bad cholesterol. Bad cholesterol is accelerated by – how does the FDA put it – by an ‘industrially produced’ food ingredient that the FDA allows to permeate the food supply. Converted in laboratories, they are known as partially hydrogenated oils or PHOs. When deadly beta-amyloids attack and disintegrate brain cells, ‘memory loss’ first occurs, then overtime, oxygen flow is diminished, limbs become incapacitated, bodily functions shutdown and eventually death occurs.”

It is the classic description of death due to most forms of dementia, including Alzheimer’s.

Though brain diseases have existed over time, the documented increase per capita in memory related disorders has sounded alarms. Research points the finger at the very ingredients that, for decades, have permeated processed foods: partially hydrogenated oils. These oils have long been banned in other nations from Europe to Asia. Yet, the FDA looked the other way as major processed food manufacturers glutted the American food supply with the “killer oils.”

An outcry by health advocates forced the FDA to announce a total ban of the oils effective as of June 18, 2018. Until mid-2018, buyer beware. The “phantom oils” remain in a vast array of processed foods as an active ingredient that is being fed daily to American families.

Though a staggering 1 in 3 seniors reportedly dies with dementia, the loss of mental capacity, whether dementia or Alzheimer’s, does not automatically occur with aging according to experts.

“Alzheimer’s [dementia] is not a normal part of aging.” — Alzheimer’s Association.

If not age, researchers queried, what is mentally derailing increasing numbers of people? It is jokingly said when a person’s body goes physically or mentally awry: “Was it something I ate?”

Diseases are caused by either genetics or the environment. According to the Alzheimer’s Association, family-inherited, early-onset Alzheimer’s Disease accounts for less than 5% of Alzheimer’s cases worldwide. Based on those extremely low statistics, researchers zeroed in on an environmental cause. In their sights are industrially-modified oils.

For almost twenty years, food activists voiced alarms that the laboratory-contrived oils remain stuck in arteries and veins far longer than oils from natural food sources. Under assault, the FDA has begrudgingly initiated a ban to slowly withdraw from processed foods the numerous forms of the oils that still saturate the marketplace. While not identified as the cause of Alzheimer’s, partially hydrogenated oils are linked to the acceleration of the build-up of the cell and nerve killing, sticky proteins — beta-amyloids — that turn into plaque and clog the brain. Beta-amyloids are the hallmarks of Alzheimer disease. Findings of top scientists are detailed in the book.

As a government agency, the FDA fails to “use reasonable care” on behalf of the American people. For decades, its inactions resulted in deaths and mental and bodily harm to millions. By law, the inactions by the FDA would be categorized as “depraved indifference” or “gross negligence.” At minimum, it is a “reckless disregard” for human life.

The damage imposed by the FDA proves costly, especially for middle-income families. The rapid increase in dementia and other brain diseases is occurring at a time when middle-income American’s discretionary spending is being tapped out. For growing numbers of families nationwide, long-term health care costs, both inside and outside of the home, are unsustainable.

The FDA functions under outdated laws that give wide leeway to corporate food giants. Charged with overseeing the overseer, it is Congress that must act to plug the loopholes:

“Corporations that are supposed to be regulated by the U.S. Food and Drug Administration may also be aided and abetted by the FDA as food corporations are allowed to ‘self-regulate’. The FDA allows major processed food manufacturers to designate their products as being ‘Generally Recognized As Safe.’ It is known by the acronym GRAS. Under the practice of GRAS, the FDA depends on the processed food industry to be its own overseer, its own inspector. Essentially, what that means is that the processed food industry is on the ‘honor system’. It is eerily akin to the tobacco industry when cigarettes were once promoted as being good for your health.”

In addition to PHOs that are consumed daily, the U.S. FDA allows other ingredients and toxins into the American food supply that are banned in other parts of the globe. Processed food manufacturers continue to pack the processed food supply with chemically manipulated ingredients that negatively impact young and old alike.

Taste biotechnology companies today have chemicals aimed at binding artificial flavors to taste bud “receptor cells” on the tongue. They are meant to ‘manipulate and trick’ the mind as substitutes or catalysts for heightened sugar, salt or other flavor sensations. With more patents in the pipeline, competition to stimulate your taste buds through both chemical and natural ingredient-alterations is expected to be fierce.

Will taste bud modifiers that reportedly “trick the mind” have a damaging impact on the developing systems of the very young and the fragile systems of aging Americans? Will the FDA do sufficient testing to determine if mind-altering chemicals will have a long-term, negative impact on consumers’ health regardless of age? If the past indicates the future, the FDA may again remain on the periphery as processed food companies continue to spoon-feed chemically-modified food and drink to unsuspecting consumers.

The charge against the FDA is malfeasance against the American public. As one major toxin is slow-walked out of the processed food supply, a stream of new, laboratory-engineered chemicals and toxins are set to permeate the marketplace. Why is the FDA loath to alert U.S. families that many of the chemicals and ingredients found in the food on their dinner tables, in children’s school menus, in fast foods, on grocery shelves, and in hospitals and nursing homes — are banned elsewhere around the world?”

Recent findings of the damaging impact of lab-modified partially hydrogenated oils come decades too late for the afflicted, dying, and loved ones lost to brain and heart diseases. Instead of a full explanation of the harm done and harm still to come, the FDA’s message remains: “Sorry about that memory loss and all of those heart attacks.” Having admitted guilt without consequence, it remains business as usual as the FDA continues to bow to corporations’ profits over citizens’ health. The determining question is — do Americans care?

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Sharon Sebastian, author of the book, “AGING: WARNING– Navigating Life’s Medical, Mental & Financial Minefields,” is a columnist, commentator, and contributor in print and on nationwide broadcasts on topics ranging from healthcare, culture, religion, and politics to domestic and global policy. Sebastian’s political and cultural analyses are published nationally and internationally. Website: www.AgingWarning.com

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Is Alzheimer’s Transmittable?

For the second time in four months, researchers have reported autopsy results that suggest Alzheimer’s disease might occasionally be transmitted to people during certain medical treatments — although scientists say that neither set of findings is conclusive.

The latest autopsies, described in the Swiss Medical Weekly on [the] 26th [of] January, were conducted on the brains of seven people who died of the rare, brain-wasting Creutzfeldt–Jakob disease (CJD). Decades before their deaths, the individuals had all received surgical grafts of dura mater — the membrane that covers the brain and spinal cord. These grafts had been prepared from human cadavers and were contaminated with the prion protein that causes CJD.

But in addition to the damage caused by the prions, five of the brains displayed some of the pathological signs that are associated with Alzheimer’s disease, researchers from Switzerland and Austria report. Plaques formed from amyloid-β protein were discovered in the grey matter and blood vessels. The individuals, aged between 28 and 63, were unusually young to have developed such plaques. A set of 21 controls, who had not had surgical grafts of dura mater but died of sporadic CJD at similar ages, did not have this amyloid signature.

Transplant trouble

According to the authors, it is possible that the transplanted dura mater was contaminated with small ‘seeds’ of amyloid-β protein — which some scientists think could be a trigger for Alzheimer’s — along with the prion protein that gave the recipients CJD. (Read more from “Is Alzheimer’s Transmittable?” HERE)

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Zika Virus Is Spreading, How Do We Stop It?

What [do we] do about the Zika virus?

As this — another viral disease — emerges, we’re again facing down a primordial threat that reminds us we are animals in an ecosystem. It’s an ecosystem that’s changing with us and because of us. Beating back Zika will require openness to innovation in both technology and policy.

The primary mosquito species now transmitting Zika virus throughout numerous countries in the Americas, Aedes aegypti, actually evolved alongside humans to target us specifically, versus other animals.

Now it is spreading its domain, due to the warming climate and its predilection for our built-up environment. Mosquitos have already altered human history before by causing millions of deaths via the spread of yellow fever and Dengue, two viruses that are closely related to Zika . . .

While we lack definitive proof that the virus caused the severe cerebral and skull deformities these newborns are suffering with, the evidence we’ve got mandates decisive action. Doctors have found Zika virus in the amniotic fluid of affected fetuses and in the placentas and brains of miscarried fetuses with microcephaly. (Read more from “Zika Virus Is Spreading, How Do We Stop It?” HERE)

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Lyme Disease–Carrying Ticks Are Now in Half of All U.S. Counties

The ticks that transmit Lyme disease, a debilitating flulike illness caused by Borrelia bacteria, are spreading rapidly across the United States. A new study shows just how rapidly. Over the past 20 years, the two species known to spread the disease to humans have together advanced into half of all the counties in the United States.

Lyme disease cases have tripled in the United States over the last 2 decades, making it the most commonly reported vector-borne disease in the Northern Hemisphere. The disease now affects around 300,000 Americans each year. If diagnosed early—a rash commonly appears around the site of the tick bite—Lyme can be effectively treated with antibiotics, but longer term infections can produce more serious symptoms, including joint stiffness, brain inflammation, and nerve pain.

To get a comprehensive map of where the two species—the blacklegged tick (Ixodes scapularis) and the western blacklegged tick (Ixodes pacificus)—were living, Rebecca Eisen and colleagues from the U.S. Centers for Disease Control and Prevention (CDC) in Fort Collins, Colorado, combined data from published papers with state and county tick surveillance data going back to 1996. They counted reports of tick sightings in each of the 3110 continental U.S. counties to determine whether those counties hosted an established population or just a few individuals. Ticks were considered “established” when sightings of at least six ticks, or two of the three life stages, had been reported in a year.

Their results, published in the Journal of Medical Entomology, show that the blacklegged tick has undergone a population explosion, doubling its established range in less than 2 decades. It is now reported in 45.7% of U.S counties, up from 30% in 1998. Blacklegged ticks are found in 37 states across the eastern United States. The rarer western blacklegged tick, restricted to just six states, has shown only modest increases in established populations, from 3.4% to 3.6% of counties. Combined, these two Lyme disease vectors are now found in half of all U.S. counties. (Read more from “Lyme Disease–Carrying Ticks Are Now in Half of All U.S. Counties” HERE)

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As Diseases Proliferate, Mosquitoes Becoming Public Enemy No. 1

As diseases go, Zika virus was always considered minor league.

It didn’t make people all that sick; most infected people had no symptoms at all. Zika was confined to a relatively narrow belt that ran from equatorial Africa to Asia.

Today, Zika has spread to Central and South America and is linked to an alarming increase in once-rare birth defects in Brazil. Although Zika was first diagnosed in Brazil in May, it’s been linked to more than 3,500 cases of microcephaly, in which infants are born with small heads and immature brain development . . .

That country is also combating outbreaks caused by dengue and chikungunya viruses, which are known for causing fevers and debilitating joint pain. Dengue can be fatal.

The USA needs to prepare for a similar scenario, in which epidemics of multiple mosquito-borne diseases break out simultaneously, according to Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, who co-wrote a new report in The New England Journal of Medicine. (Read more from “As Diseases Proliferate, Mosquitoes Becoming Public Enemy No. 1” HERE)

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Terrifying Disease May Cause Birth Defects – and Experts Think It’s Coming to the US

By Julia Belluz. The Zika virus, a rare tropical disease that’s causing a panic in Brazil — because it may lead to babies being born with abnormally small heads — has now made its way to Puerto Rico. And experts fear the United States could be next.

Until last year, the Zika virus, which is spread by mosquitoes, was mainly confined to Africa and Asia. But in 2015 the disease made the leap to the Western Hemisphere, affecting more than a million people in Brazil. It’s since spread to Colombia, Venezuela, Mexico, and nine other countries. Last week, the first confirmed case in Puerto Rico was reported.

The puzzling spread of Zika is part of an uptick of mosquito-borne illnesses — including West Nile, dengue, and chikungunya — in areas that have never experienced them before.

“It’s spreading really fast,” said Scott Weaver, the director of the Institute for Human Infections and Immunity at the University of Texas Medical Branch in Galveston. “I think [the Zika virus] is going to be knocking on the doorstep in places like Florida and Texas probably in the spring or summer.”

The overwhelming majority of people who come into contact with Zika — through bites from infected mosquitoes — seem to experience either a flu-like illness or no symptoms at all. (Read more from “Terrifying Disease May Cause Birth Defects – and Experts Think It’s Coming to the US” HERE)
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Devastating Virus May Be Sexually Transmitted

By Derrick Aarons. A virologist at the Bernhard-Nocht Institute for Tropical Medicine in Hamburg, Germany, has suggested that Zika virus infection is the only vector-borne disease that may be transmitted by sexual intercourse.

The first suggestion that you could get Zika virus infection from both a mosquito as well as a sexual partner came in 2008, when an American scientist contracted Zika in Senegal and fell ill a few days after returning home to northern Colorado. His wife got Zika soon after, even though she had not travelled anywhere far for several months. More weight was placed on this suspicion by research published in 2015 that found the presence of the Zika virus in semen. (Read more about this disease that is causing increasing numbers of birth defects HERE)

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Zombie Apocalypse A Possibility? Rise in Zombie-Like Infection Should Trigger An International Call of Action, An Expert Reveals

Can a zombie apocalypse really occur? Tara Smith, an associate professor from Ohio’s Kent State University is issuing an international call to action to fund and promote studies on how to prevent a possible zombie outbreak.

“Zombie expert Matt Mogk defines a zombie with three criteria: it is a reanimated human corpse; it is relentlessly aggressive, and it is biologically infected and infectious. But Mogk notes that this definition has been altered by the recognition of “rage” zombies, which are infected but still alive,” Smith wrote on a recently published BMJ study.

Smith cited several scientific studies, news reports and fictional works to back up her research. As listed on Discovery News, the author specified three possible pathogens that could cause an outbreak: the Black Plague bacteria Y. pestis, mad cow disease as well as the Cordyceps fungus.

Out of the three pathogens, it is the Cordyceps fungus which is the most common, with 400 known species. According to the publication, the parasitic fungus invades the body of its host and takes over, using the body as a means to make the fungus spores spread.

In a report by EurekAlert, Smith believes that the increase of similar zombie pathogens should be a sign that additional attention and funding should be provided into studying possible disease outbreaks. (Read more from “Zombie Apocalypse a Possibility? Rise in Zombie-Like Infection Should Trigger an International Call of Action, an Expert Reveals” HERE)

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CDC: Antibiotic-Resistant Shigella Spreading, Here Are The High-Risk Groups, How You Catch It

It is late on a Sunday night and your son is clutching his stomach complaining of pain. He feels warm so you test his temperature and he definitely has a fever. He says he needs to use the bathroom and you are shocked to see that he has passed bloody diarrhea. You rush him to the emergency room in hopes that whatever he has is easily treated. A few days later you discover that your son actually has an antibiotic-resistant Shigella and that one of the few treatments available is not only more expensive but also more harmful than the antibiotics formerly used while not being as effective. You wonder how in the world your son contracted this disease which is spread through fecal matter. Could it have been at the party for new international students you attended on Friday night? Undoubtedly it would have been at that party. If you had only known of this bacterial infection common to the developing world then you could have taken steps to prevent it in your son.

The problem is that there are are some misconceptions regarding certain diseases in the U.S and where they are likely to originate. The CDC usually does a pretty good job looking at disease outbreaks and relaying to the public information by which they can protect themselves. However, unless the public is regularly checking the CDC website for themselves, they may not be aware of current disease outbreaks as the popular news websites don’t regularly post those type of stories. Sometimes these sites direct the information only to the segment of the population that they believe is affected. People who are not related to that specific segment of the population may be harmed by not getting the information they need to protect themselves and their families.

A good example of this is the recent outbreak of drug resistant Shigella that made news when it affected Kansas City. With a little research one can find that it has been affecting parts of the United States since May 2014. By February 2015 it had already been found in 32 states. By April the CDC decided it was important to let the public know how the outbreak started and how people could protect themselves. According, to their research about 50 percent of the cases originated in the homeless population and the other cases originated with international travelers. This multi-drug resistant Shigella has specifically been traced back to mostly international travellers from India and Dominican Republic. This information is not surprising once one looks at the rate of Shigella in those areas. They are both developing areas which do not have modern sewage systems.

It is also interesting that the CDC acknowledges that in the US the main outbreaks are occurring among child care facilities, gay men, and the homeless. At this same time some major news sources are mainly discussing Shigella spreading among children in child care settings. They are ignoring the fact that Shigella is also spread by international travelers, gay/bisexual men and the homeless. This is something that the general population should be aware of!

What should we learn from this information? First, this means that people traveling to developing countries should follow the advice from the CDC on how to avoid contracting Shigella. Second, residents of the US should be cautious of those immediately returning or coming from developing countries because the traveler could be infected with Shigella. The incubation period is about two days but a person may still infect others long after they are no longer showing signs of sickness. This is one reason Shigella is so contagious and at times difficult to contain.

This subject is important to me personally because I am related to one of the at risk groups by being married to a man from a developing country. When we travel internationally we are always aware of what we should be doing to protect ourselves from various diseases. However, we know that not everyone who travels internationally is as conscientious as we are. I am aware of this because many of my international friends travel back to the country of their origin, then spent part of their vacation sick from things as Shigella. They thought that since the country was their childhood home, they did not have to take the same precautions (drinking bottled water, not eating salads/fruit) that other travelers needed to take.

The media must be more diligent in informing the public concerning the entire risks of disease epidemics so that the populace can help stem the spread of infections and stop the outbreak.

Sources:

https://www.cdc.gov/shigella/general-information.html
https://www.cdc.gov/mmwr/preview/mmwrhtml/mm6412a2.htm
https://www.cdc.gov/media/releases/2015/p0402-multidrug-resistant-shigellosis.html
https://www.cdc.gov/shigella/general-information.html#transmission