Study on Puberty Blockers in Teens ‘Confirms Massive Decrease in Bone Density’

California endocrinologist Dr. Michael Laidlaw observed on Twitter this week that a 2020 preprint of a study on puberty blockers administered to 12-15-year-old gender-dysphoric youth confirmed a “massive decrease in bone density of patients relative to their peers.”

“The graph shows the baseline spine bone density and then the decrease over time,” Laidlaw continued in the thread.

As a “preprint” published online at medRxiv.org, the article, titled “Short-term outcomes of pubertal suppression in a selected cohort of 12 to 15 year old young people with persistent gender dysphoria in the UK,” is new research that has yet to be peer-reviewed.

The lead investigators of the study, which included 44 patients, are from the U.K.’s Tavistock and Portman NHS trust, which operates a “gender identity development service” (GIDS) for children.

“There was no change from baseline in spine BMD [bone mineral density] at 12 months nor in hip BMD at 24 and 36 months, but at 24 months lumbar spine BMC [bone mineral content] and BMD were higher than at baseline …,” the researchers wrote.

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